Ziem Protocol For Chemical Injuries/Sensitivities"
("Multiple Chemical Sensitivities")

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Published biochemical studies show that Chemical Injury symptoms come from a self-perpetuating cycle of tissue injury and chronic inflammation. Within traditional limits, these body responses help protect the body from short-term invasive influences. However, above a certain exposure threshold and duration (often seen in today's environment), the process becomes unstable when higher levels of environmental pollutants in the body induce excessive nitric oxide in the cells. This forms excessive peroxynitrite, which injures these cells and mitochondria (where energy is produced), over-activating NMDA receptors which induce more nitric oxide (the "Inducible Nitric Oxide/Peroxynitrite Cycle"). Susceptibility to this vicious cycle can be increased by nutritional and/or genetic deficiencies as well as by duration and/or intensity of recent or past pollutant exposure or mold exposures ("Mycotoxins"), explaining differing susceptibility in different people.

The body becomes more sensitive to new chemical exposures when it already has a build-up of previous toxic chemicals and/or heavy metals (in any combination), which can build up unnoticed and often have a half-life in the body of many years. Conventional testing does not help much. (Ever been told "Your tests are normal" when you still feel sick?) Drugs do not get rid of the accumulated toxic burden (because the body didn't get sick from "drug deficiency").

Although this is a whole-body process, the type of exposure determines the body function most prominently impaired, such as brain function, liver detoxification, reactive airway disease, digestive function, or immune system. (For example, some cases of autoimmune disease are triggered by toxic effects of Mercury on the immune system.) However, every organ of the body is affected and can adversely affect every other part of the body. The “Gulf War Syndrome”, which was denied by the Veterans Administration for years, is a well-known example of occupational Chemical Injury. Parkinsonism is highly correlated with past pesticide exposure (many years earlier).

The Ziem “Neural Protocol” for Chemically Injured patients is based upon specialized lab test results and patient response, to promote healing from this frustrating disability. The Protocol name comes from the observation that the nervous system (especially the brain) is more sensitive to Chemical Injury and is especially difficult to treat (no known drugs can do this). A customized treatment approach based on understanding inflammation biochemistry is needed. This includes avoiding ongoing noxious exposures and taking targeted supplements to address appropriate biochemical leverage points for reducing oxidative damage to cells and scavenging excess nitric oxide. These nutritional needs are very different from the minimum needed for maintaining a healthy body.

If you are interested in following this protocol, I can help you do so. This may require different Questionnaires and Lab Tests as well as different kinds of treatment than with other kinds of patients (but not drugs, which often act as additional toxic chemicals in chemically-sensitized people). NOTE: Avoiding even minimal further exposure by EFFECTIVE ENVIRONMENTAL CONTROLS is the most important first step.

For more information on Chemical Injuries, see

NOTE: Chronic Lyme Disease can mimic Chemical Injury, but is more likely to fluctuate in severity ("good and bad days"), and to migrate around different parts of the body (moving to different sides of the body or to different organ systems), and/or get better or worse temporarily after a course of antibiotics. Chronic Lyme symptoms can include fatigue, migrating joint and muscle pains, sleep disorders, memory and concentration problems, and/or fluctuating neuropathic pain (tingling, numbness, burning). Many reported that their physical and/or mental health was not good on at least 15 days in the previous month.

If you may have been bitten by ticks (often in wooded areas) and think you may have Chronic Lyme Disease, see the Horowitz Lyme-MSIDS Questionnaire.
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